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SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
USERS' SCORE
Good
Based on 11 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Milk Thistle Seed 30:1 Extract(Silybum marianum) (Fruit/Seed) (80% [120 mg] Total Flavonoids)
150 mg
†
Top Medical Research Studies
9
Silybin shows promise for autoimmune disorders
Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation.
High potential therapeutic relevance
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows immunosuppressive effects
Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis.
Potential treatment for autoimmune disorders.
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
9
Silibinin shows promise in autoimmunity
The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis.
Moderately relevant to autoimmune therapy
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
Most Useful Reviews
9.5
Reduces fatigue
I find Jarrow brand Milk Thistle to be the best for my excessive daytime sleepiness disorder. I can safely take one capsule three times a day, which helps alleviate my tiredness. Within 45 minutes of taking a capsule, I feel more awake. Just remember not to exceed three capsules a day.
Read More
9.5
Alleviates discomfort
I adore Milk Thistle. I experienced bile issues and discomfort but after a week of taking it, all symptoms vanished. I can take it continuously without interruption, so I highly recommend it. I even ordered some for my mother.
Read More
8.8
Improves liver function
Milk Thistle has significantly improved my liver condition caused by long-term eating disorders. After taking one capsule twice daily after meals, my health has greatly improved, and my test results are favourable. I’m ordering more as it has made a substantial difference.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
9
Silybin shows promise for autoimmune disorders
Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation.
High potential therapeutic relevance
We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.
The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.
Read More
9
Silibinin shows promise in autoimmunity
The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis.
Moderately relevant to autoimmune therapy
We explored how silibinin, a compound derived from milk thistle, may influence autoimmune disorders like rheumatoid arthritis (RA).
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Through our study, which included both healthy individuals and RA patients, we found that silibinin enhances the expression of estrogen receptor beta (ERβ) and promotes apoptosis in T lymphocytes, leading to reduced inflammation.
It also acts on microRNA-155, which is linked to RA's progression. These findings suggest that silibinin holds promise as both a treatment option and a dietary supplement for managing autoimmune diseases.
Read More
9
Silymarin boosts insulin production
Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic β-cells in a pancreatectomy model.
Highly relevant diabetes treatment insight
We analyzed how Silymarin affects the Pdx1 gene expression and insulin production in a model of diabetes following partial pancreatic removal. With 72 rats divided into groups, those treated with Silymarin showed significant increases in both Pdx1 and insulin levels compared to untreated rats.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Notably, the treatment led to a remarkable boost in β-cell proliferation, enhancing insulin secretion and reducing blood sugar levels. These findings highlight Silymarin's potential to support the recovery of insulin-producing cells in diabetic conditions.
Read More
9
Silibinin shows immunosuppressive effects
Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis.
Potential treatment for autoimmune disorders.
We explored the effects of silibinin, derived from silymarin (Silybum marianum), on autoimmune disorders, particularly multiple sclerosis. In a study using an animal model, we observed that silibinin notably reduced signs of spinal cord damage and inflammation, suggesting its potential immunosuppressive effects.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Additionally, silibinin was found to modulate cytokine production by lowering pro-inflammatory Th1 cytokines while increasing anti-inflammatory Th2 cytokines. This indicates that silibinin could be both immunosuppressive and beneficial for managing autoimmune responses, though further research is necessary to confirm its effectiveness in clinical settings.
Read More
8
Silymarin shows promise for MS
Immunoregulatory Effects of Silymarin on Proliferation and Activation of Th1 Cells Isolated from Newly Diagnosed and IFN-ß-Treated MS Patients.
Relevant findings for immune modulation.
We explored the impact of silymarin, a compound from milk thistle, on the immune system in patients with multiple sclerosis (MS). By isolating Th1 cells from both newly diagnosed and treatment-receiving patients, we assessed how silymarin affected cell activity at various doses and times.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Our results indicated that silymarin effectively reduced Th1 cell proliferation and interfered with the production of key inflammatory markers. However, in patients treated with interferon-beta, there were mixed results over time, where some increases in inflammatory markers were noted. Overall, silymarin appears to hold promise as an immunomodulatory agent for MS.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.1
9.5
Reduces fatigue
I find Jarrow brand Milk Thistle to be the best for my excessive daytime sleepiness disorder. I can safely take one capsule three times a day, which helps alleviate my tiredness. Within 45 minutes of taking a capsule, I feel more awake. Just remember not to exceed three capsules a day.
Read More
9.5
Normalises enzymes
After taking Milk Thistle for a month due to elevated liver enzymes, my recent blood work showed normal levels. This isn't the first time it has worked for me, which is why I continue to use it.
9.5
Alleviates discomfort
I adore Milk Thistle. I experienced bile issues and discomfort but after a week of taking it, all symptoms vanished. I can take it continuously without interruption, so I highly recommend it. I even ordered some for my mother.
8.8
Improves liver function
Milk Thistle has significantly improved my liver condition caused by long-term eating disorders. After taking one capsule twice daily after meals, my health has greatly improved, and my test results are favourable. I’m ordering more as it has made a substantial difference.
8.8
Beneficial for pets
Milk Thistle has been miraculous for my family and pets. Our dogs with high liver enzymes and pancreatitis have shown significant improvement. It also seems to help with our autoimmune issues. Consult your doctor, but it’s been a great supplement for our whole family.
